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Index > Protein center > Crtc2(Gene name) > Mouse
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  • Crtc2 (Gene name),
  • CREB-regulated transcription coactivator 2 (Protein name ),  CRTC2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Crtc2(Torc2);
    Protein name:
    CREB-regulated transcription coactivator 2;
    Alternative:
    Transducer of regulated cAMP response element-binding protein 2(TORC-2;Transducer of CREB protein 2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (By similarity). Interacts with PPP3CA/calcineurin alpha, SIK2 and 14-3-3 proteins, YWHAB and YWHAG (By similarity). Interaction with RFWD2/COP1 mediates nuclear export and degradation of CRTC2.
    Function:
    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.
    Subcellular Location:
    Cytoplasm Nucleus Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
    Protein Attributes:
    Sequence length:
    692
    Sequence:
    50:
    MATSGANGPG | SATASASNPR | KFSEKIALQK | QRQAEETAAF | EEVMMDIGST | 
    100:
    RLQAQKLRLA | YTRSSHYGGS | LPNVNQIGCG | LAEFQSPLHS | PLDSSRSTRH | 
    150:
    HGLVERVQRD | ARRMVSPLRR | YPRHIDSSPY | SPAYLSPPPE | SGWRRMMPWG | 
    200:
    NLPAEKGQLF | RLPSALNRTS | SDSALHTSVM | NPNPQDTYPG | PTPPSVLPSR | 
    250:
    RGGGFLDGEM | DAKVPAIEEN | VVDDKHLLKP | WDAKKLSSSS | SRPRSCEVPG | 
    300:
    INIFPSPDQP | ANVPVLPPAM | NTGGSLPDLT | NLHFPPPLPT | PLDPEETVYP | 
    350:
    SLSGGNSTTN | LTHTMTHLGI | SGGLGLGPSY | DVPGLHSPLS | HPSLQSSLSN | 
    400:
    PNLQASLSSP | QPQLQGSHSH | PSLPASSLAH | HALPTTSLGH | PSLSAPALSS | 
    450:
    SSSSSSTSSP | VLSAPPYPAS | TPGASPRHRR | VPLSPLSLPA | GPADARRSQQ | 
    500:
    QLPKQFSPTM | SPTLSSITQG | VPLDTSKLPT | DQRLPPYPYS | PPSLVIPTHP | 
    550:
    PTPKSLQQLP | SQACLVQPSG | GQPPGRQPHY | GALYPPGSSG | HGQQPYHRPI | 
    600:
    NDFSLGNLEQ | FNMESPSTSL | VLDPPAFSEG | PGFLGSEGSM | SGPQDPHVLN | 
    650:
    HQNLTHCSRH | GSGPNIILTG | DSSPGFSKEI | AAALAGVPGF | EVSASGLELG | 
    692:
    LGLEDELRME | PLGLEGLTML | SDPCALLPDP | AVEDSFRSDR | LQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CREB-regulated transcription coactivator 2
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    E10676h
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    ELISA Kit for Mouse CREB-regulated transcription coactivator 2
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    E10676m
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    Packing:
    96T
    ELISA Kit for Mouse CREB-regulated transcription coactivator 2
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    E10676r
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    ELISA Kit for Mouse CREB-regulated transcription coactivator 2
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    E10676b
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    Packing:
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    CLIA Kit for Mouse CREB-regulated transcription coactivator 2
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    U10676r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse CREB-regulated transcription coactivator 2
    Cat.:
    U10676h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CREB-regulated transcription coactivator 2
    Cat.:
    U10676b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CREB-regulated transcription coactivator 2
    Cat.:
    U10676m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse CREB-regulated transcription coactivator 2
    Polyclonal Antibody for Mouse CREB-regulated transcription coactivator 2
    Cat.:
    P10676Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse CREB-regulated transcription coactivator 2
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    P10676Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse CREB-regulated transcription coactivator 2
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    P10676Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse CREB-regulated transcription coactivator 2
    Monoclonal Antibody for Mouse CREB-regulated transcription coactivator 2
    Monoclonal Antibody for Mouse CREB-regulated transcription coactivator 2
    Monoclonal Antibody for Mouse CREB-regulated transcription coactivator 2
    Protein for Mouse CREB-regulated transcription coactivator 2
    Protein for Mouse CREB-regulated transcription coactivator 2
    Protein for Mouse CREB-regulated transcription coactivator 2
    Protein for Mouse CREB-regulated transcription coactivator 2

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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
      tissue: Spleen.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Liver.
      tissue: Mammary tumor.
      tissue: Salivary gland.
    3. 3.
      "The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism."
      Koo S.-H. , Flechner L. , Qi L. , Zhang X. , Screaton R.A. , Jeffries S. , Hedrick S. , Xu W. , Boussouar F. , Brindle P. , Takemori H. , Montminy M.
      Nature437:1109-1111(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-171;TISSUE SPECIFICITY
    4. 4.
      "The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin."
      Shaw R.J. , Lamia K.A. , Vasquez D. , Koo S.-H. , Bardeesy N. , Depinho R.A. , Montminy M. , Cantley L.C.
      Science310:1642-1646(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-171;SUBCELLULAR LOCATION
    5. 5.
      "Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2."
      Dentin R. , Liu Y. , Koo S.-H. , Hedrick S. , Vargas T. , Heredia J. , Yates J. III , Montminy M.
      Nature449:366-369(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RFWD2;PHOSPHORYLATION AT SER-171;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-171; VAL-214; PRO-215 AND LYS-628
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    7. 7.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock."
      Sakamoto K. , Norona F.E. , Alzate-Correa D. , Scarberry D. , Hoyt K.R. , Obrietan K.
      J. Neurosci.33:9021-9027(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    9. 9.
      "Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism."
      Han H.S. , Jung C.Y. , Yoon Y.S. , Choi S. , Choi D. , Kang G. , Park K.G. , Kim S.T. , Koo S.H.
      Sci. Signal.7:RA19-RA19(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT ARG-51; ARG-99; ARG-120; ARG-123; ARG-161 AND ARG-168
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